The Role of MEG3 in the Activation of Toll Like Receptor 3 in Prostate Cancer Cells

Objective: Prostate cancer accounts for approximately 10% of new cases diagnosed in men worldwide. Toll like receptors (TLRs) play a crucial role the progression cancer. Furthermore, expression level TLRs is mediated by different transcription factors and non-coding RNAs. Therefore, aim this study was to investigate potential regulatory MEG3 interaction TLR3 with prostate cells. Materials Methods: In study, PC-3, LNCaP HUVEC cells were used. To stimulate expression, Poly I:C used ligand less cytotoxic concentration determined WST-1 analysis. The relative gene levels analyzed RT-PCR. Results: According results, 5 µM chosen as stimulation activity. mRNA (3.19-, 1.90-, 1.90-fold) (6.17-, 5.75- 2.27-fold) significantly increased cells, respectively after (p<0.05). Additionally, 2.33- 10.93-fold PC-3 respectively, compared Conclusion: conclusion, activation signaling pathway through promoted especially castration-resistant Thus, our preliminary data suggests that could modulate